Identification of Mirror Repeats within the SWI 6 Gene of Saccharomyces cerevisiae

Abstract

The SWI6 gene in Saccharomyces cerevisiae, also known as Switching Deficient 6, encodes a protein essential for the formation and function of the SBF complex (Swi4/Swi6 complex), a critical regulator of the cell cycle. SWI6 plays a pivotal role in facilitating the G1-to-S phase transition by partnering with the transcription factor Swi4 to activate the expression of genes necessary for DNA replication and cell division. Through its involvement in chromatin remodeling and transcriptional activation, SWI6 ensures proper cell cycle progression, particularly in the initiation of DNA synthesis. Mutations or defects in SWI6 disrupt the cell cycle, resulting in cell cycle arrest and impaired cellular proliferation. This study highlights the fundamental role of SWI6 in the regulation of cell division and provides insights into the molecular mechanisms controlling genetic stability in eukaryotic cells through the analysis of mirror repeats using the FASTA–Parallel Complement–BLAST (FPCB) method. To analyze SWI6's sequence and functional homology, we applied the FPCB FASTA–Parallel Complement–BLAST method, facilitating the identification of conserved motifs. Additionally, our research investigates mirror repeats in the SWI6 gene, exploring their potential impact on genetic stability and sequence evolution.